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Loring "Red" Nichols is a cornet-playing country boy who goes to New York in the 1920s full of musical ambition and principles

. He gets a job playing in Wil Paradise's band, but quits to pursue his dream of playing Dixieland jazz. He forms the "Five Pennies" which features his wife, Bobbie
, as vocalist. At the peak of his fame, Red and Bobbie's daughter 
, Dorothy, develops polio. ..